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There are currently no direct head-to-head clinical trials evaluating bortezomib-melphalan-prednisone VMP versus. in untreated elderly MM patients. Maintenance therapy with bortezomib plus thalidomide or bortezomib plus prednisone in elderly multiple myeloma patients included in the GEM2005MAS65. Appropriate studies performed to date have not demonstrated specific problems that would limit the usefulness of prednisone in the elderly.
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Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma. Oral melphalan, prednisone, and thalidomide in elderly patients with multiple myeloma updated results of a randomized controlled trial.